2024 Leveraging next-generation materials for cancer neuroscience therapies in the central nervous system
J. D. Bernstock, B. R. Johnston, G. K. Friedman, E. A. Chiocca, R. Langer, S. S. Srinivasan
Nature Review Materials
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2024 An ingestible self-propelling device for intestinal reanimation
S. S. Srinivasan, J. Dosso, H. Huang, G. Selsing, A. Alshareef, J. Kuosmanen, K. Ishida, J. Jenkins, W. A. M. Madani, A. Hayward, G. Traverso
Science Robotics
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Contre les problèmes de ventre, avalez un petit robot !
Constipations, ballonnements, douleurs abdominales… Des chercheurs américains ont développé une méthode innovante pour rétablir le bon fonctionnement de l’intestin.
Oliver Hertel | Le Point
February 28, 2024
2023 A Vibrating Ingestible BioElectronic Stimulator Modulates Gastric Stretch Receptors for Illusory Satiety.
S. S. Srinivasan, A. Alshareef, A. Hwang, C. Bryne, J. Kuosmann, K. Ishida, J. Jenkins, S. Liu, W. A. M. Madani, A. M. Hayward, N. Fabian, G. Traverso
Science Advances
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This Vibrating “Pill” Could Help You Lose Weight
It may be a more cost-effective alternative to popular injectable treatments like Ozempic and Wegovy.
Miriam Fauzia | Inverse
December 22, 2023
2023 Digitization and access-conscious engineering increase access to prostheses.
A. Cherian, S. Srinivasan
Nature Bioengineering
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2023 Implantable microdevices for treating brain tumors.
A. G. Yearley, R. V. Patel, S. E. Blitz, S. Park, A. M. Madinger, J. Li, B. R. Johnston, P. P. Peruzzi, S. Lee, S. S. Srinivasan, J. D. Bernstock
Device
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2023 Patient-Centered Frameworks for Pain Neuromodulation Therapy: Overcoming Commercial and Regulatory Constraints to Optimize Therapy for Neural Interfaces.
S. S. Srinivasan, A. Venkatasubramanian, R. North, P. Konrad
Neuromodulation: Technology at the Neural Interface
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2023 Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss.
E. Rousseau, R. Raman, T. Tamir, A. Bu, S. Srinivasan, N. Lynch, R. Langer, F. M. White, M. J. Cima
Biomaterials
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2023 Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice.
R. Hotta, A. Rahman, S. Bhave, R. Stavely, W. Pan, S. Srinivasan, G. de Couto, L Rodriguez-Borlado, R. Myers, A. J. Burns, A. M. Goldstein
Stem Cell Research & Therapy
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2023 Adaptive conductive electrotherapeutic scaffolds for enhanced peripheral nerve regeneration and stimulation.
S. S. Srinivasan, L. Gfrerer, P. Karandikar, A. Som, A. Alshareef, S. Liu, H. Higginbotham, K. Ishida, A. Hayward, S. P Kalva, R. Langer, G. Traverso.
Med
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2023 Location-aware ingestible microdevices for wireless monitoring of gastrointestinal dynamics.
S. Sharma, K. Ramadi, N. Poole, S. S. Srinivasan, K. Ishida, J. Kuosmanen, J. Jenkins, F. Aghlmand, M. Swift, M. Shapiro, G. Traverso, A. Emami.
Nature Electronics
Ingestible sensor could help doctors pinpoint GI difficulties
The sensor sends out its location as it moves through the GI tract, revealing where slowdowns in digestion may occur.
Anne Trafton | MIT News Office
February 13, 2023
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2022 Low-cost gastrointestinal manometry via silicone–liquid-metal pressure transducers resembling a quipu.
K. Nan, S. Babaee, W. W. Chan, J. L. P. Kuosmanen, V. R. Feig, Y. Luo, S. S. Srinivasan, C. M. Patterson, A. M. Jebran, G. Traverso.
Nature Biomedical Engineering
A simple diagnostic tool for gastrointestinal disorders
Inspired by an ancient technology, engineers design a sensor that can measure pressure inside the digestive tract.
Anne Trafton | MIT News Office
February 13, 2023
Read this publication on Nature Biomedical Engineering.
2022 RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.
S. S. Srinivasan, A. Alshareef., A. V. Hwang, J. Kuosmanen, K. Ishida, J. Jenkins, S. Liu, W. A. M. Madani, A. Lopes, J. Morimoto, R. Langer, G. Traverso.
Science Robotics
Ingestible sensor could help doctors pinpoint GI difficulties
A capsule that tunnels through mucus in the GI tract could be used to orally administer large protein drugs such as insulin.
Anne Trafton | MIT News Office
September 28, 2022
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2022 Agonist-antagonist muscle strain in the residual limb preserves motor control and perception after amputation.
H. Song, E. A. Israel, S. Gutierrez-Arango, A. C. Teng, S. S. Srinivasan, L. E. Freed, H. M. Herr
Communications Medicine
Clinical evaluation of sensorimotor responses and the degree of agonist-antagonist muscle strain (AMS) for participant’s residual limb muscles.
Read this publication on Communications Medicine.
2022 A cutaneous mechanoneural interface for neuroprosthetic feedback.
S. S. Srinivasan, H. M. Herr
Nature Biomedical Engineering
With her innovation, this engineer wants to restore an amputee’s sense of touch
Shriya Srinivasan’s intriguing research is attracting attention
Anissa Gardizy | Globe Staff
February 15, 2021
Top collegiate inventors awarded 2020 Lemelson-MIT Student Prize
Students around the country recognized for innovative solutions to better single-use plastic, spacecraft and aircraft fuel gauges, surgery techniques, and more.
Lemelson-MIT Program
April 29, 2020
Read this publication on Nature Biomedical Engineering.
2022 Respiratory Care Innovation in Times of Crisis.
S. S. Srinivasan, R. Mondal, K. B. Ramadi
Journal of Emergency Nursing
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2021 Powering implantable and ingestible electronics.
S. Yang, V. Sencadas, S. Sean You, N. Z. Jia, S. S. Srinivasan, H. Huang, A. E. Ahmed, J. Y. Liang, G. Traverso
Advanced Functional Materials
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2021 Magnetomicrometry.
C. R. Taylor, S. S. Srinivasan, S. H. Yeon, M. K. O’Donnell, T. J. Roberts, H. M. Herr
Science Robotics
Magnets could offer better control of prosthetic limbs
Anne Trafton | MIT News Office
August 18, 2021
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2021 Pre-emptive Innovation Infrastructure for Medical Emergencies: Accelerating Healthcare Innovation in the Wake of a Global Pandemic.
K. B. Ramadi, S. S. Srinivasan
Frontiers in Digital Health
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2021 A crisis-responsive framework for medical device development applied to the COVID-19 pandemic.
M. Antonini, D. Plana, S. S. Srinivasan, L. Atta, A. Achanta, H. Yang, A. K. Cramer, J. Freake, M. S. Sinha, S. H. Yu, N. R. LeBoeuf, B. Linville-Engler, P. K. Sorger
Frontiers in Digital Health
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2021 Neural interfacing architecture enables enhanced motor control and residual limb functionality post-amputation.
S. S. Srinivasan, S. Gutierrez-Arango, A. C. Teng, E. Israel, H. Song, Z. K. Bailey, M. J. Carty, L. E. Freed, H. M. Herr
Proceedings of the National Academy of Sciences
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2021 Agonist-antagonist myoneural interfaces in above-knee amputation preserve distal joint function and perception.
S. S. Srinivasan, H. M. Herr, T. R. Clites, S. Gutierrez-Arango, A. Teng, L. Beltran, H. Song, E. Israel, M. J. Carty
Annals of Surgery
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2021 Reinventing extremity amputation in the era of functional limb restoration.
H. M. Herr, T. R. Clites, S. S. Srinivasan, S. G. Talbot, G. A. Dumanian, P. S. Cederna, M. J. Carty
Annals of Surgery
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2020 Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs.
S. S. Srinivasan, G. Tuckute, J. Zou, S. Gutierrez-Arango, H. Song, R. L. Barry, H. M. Herr
Science Translational Medicine
New surgery may enable better control of prosthetic limbs
Reconnecting muscle pairs during amputation gives patients more sensory feedback from the limb.
Anne Trafton | MIT News Office
February 15, 2021
Virtual Event – ‘Augmented’: The future of brain-controlled prosthetic limbs
Gideon Gil | STAT
February 25, 2022
Read this publication on Science Translational Medicine.
2020 Electroceuticals in the Gastrointestinal Tract.
K. Ramadi, S. S. Srinivasan, G. Traverso
Trends in Pharmaceutical Sciences
Read this publication on Trends in Pharmaceutical Sciences.
2020 Pressure based MRI-compatible muscle fascicle length and joint angle estimation.
H. Song, E. Israel, S. S. Srinivasan, H. M. Herr
Journal of Neuroengineering and Rehabilitation
Read this publication on Journal of Neuroengineering and Rehabilitation
2020 A rapidly deployable individualized system for augmenting ventilator capacity.
S. S. Srinivasan, K. B. Ramadi, F. Vicario, D. Gwynne, A. Hayward, D. Lagier, R. Langer, J. J. Frassica, R. M. Baron, G. Traverso
Science Translational Medicine
Delivering life-saving oxygen during a pandemic
MIT mechanical engineers have developed technologies to help hospitals around the world provide life-saving oxygen to patients with Covid-19 and other respiratory illnesses.
Mary Beth Gallagher | Department of Mechanical Engineering
January 5, 2021
MIT Students’ Project Prana is Bringing Low-Cost Ventilators to India Amid the Covid Crisis
MIT students Shriya Srinivasan and Rajib Mondal’s Project Prana is making multiplex ventilators called iSave that will be priced at Rs 45,000. Made out of Chennai, these ventilators can connect one ventilator to two patients, can be cutomised, and control the parameters as well.
Sindhu Kashyaap | YourStory
Read this publication on Science Translational Medicine.
2019 Democratizing innovation through grass-roots entrepreneurship: lessons from efforts to address the opioid epidemic in the United States.
S. S. Srinivasan, K. B. Ramadi, A. Ippolito, R. Atun
BMJ Global Health
Read this publication on BMJ Global Health.
2019 Retinal supplementation augments optogenetic stimulation efficacy in vivo.
S. S. Srinivasan, B. Schelhaas, B. Maimon, H. Song, H. M. Herr
Journal of Neural Engineering
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2019 Caprine models of the agonist-antagonist myoneural interface implemented at the above-and below-knee amputation levels.
T. R. Clites, M. J. Carty, S. S. Srinivasan, S. G. Talbot, R. Brånemark, H. M. Herr
Plastic and Reconstructive Surgery
Read this publication on Plastic and Reconstructive Surgery.
2019 Health diplomacy through health entrepreneurship: using hackathons to address Palestinian-Israeli health concerns.
K. B. Ramadi, S. S. Srinivasan, R. Atun
BMJ Global Health
Read this publication on BMJ Global Health.
2019 Polyimide electrode-based electrical stimulation impedes early stage muscle graft regeneration.
S. S. Srinivasan, K. Vyas, M. McAvoy, P. Calvaresi, O. F. Khan, R. Langer, D. G. Anderson, H. M. Herr
Frontiers in Neurology
Read this publication on Frontiers in Neurology.
2019 Towards functional restoration for persons with limb amputation: A dual-stage implementation of regenerative agonist-antagonist myoneural interfaces.
S. S. Srinivasan, M. Diaz, M. Carty, H. M. Herr
Scientific Reports
Read this publication on Scientific Reports.
2019 Gold Nanoparticle-Based Fluorescent Theranostics for Real-Time Image-Guided Assessment of DNA Damage and Repair.
S. S. Srinivasan, R. Seenivasan, A. Condie, S. L. Gerson, Y. Wang, C. Burda
International Journal of Molecular Sciences
Read this publication on International Journal of Molecular Sciences
2018 Closed-loop functional optogenetic stimulation.
S. S. Srinivasan, B. E. Maimon, M. Diaz, H. Song, H. M. Herr;
Nature Communications
Stimulating Muscles with Light Could Soon Treat Paralysis
Using optogenetics, researchers could precisely steer a mouse’s leg muscles.
Dan Robitzski | Futurism
December 13, 2018
Leg nerves activated by light offer new path to restoring mobility
Using optogenetics, researchers could precisely steer a mouse’s leg muscles.
Becky Ham | MIT Media Lab
Read this publication on Nature Communications.
2018 The Ewing amputation: The first human implementation of the agonist-antagonist myoneural interface.
T. R. Clites, H. M. Herr, S. S. Srinivasan, A. N. Zorzos, M. J. Carty
Plastic and Reconstructive Surgery Global Open
Read this publication on Plastic and Reconstructive Surgery Global Open.
2018 Optogenetic peripheral nerve immunogenicity.
B. E. Maimon, M. Diaz, E. Revol, A. M. Schneider, B. Leaker, C. E. Varela, S. S. Srinivasan, M. B. Weber, H. M. Herr
Scientific Reports
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2018 Spectrally distinct channelrhodopsins for two-colour optogenetic peripheral nerve stimulation.
B. E. Maimon, K. Sparks, S. S. Srinivasan, A. N. Zorzos, H. M. Herr
Nature Biomedical Engineering
Read this publication on Nature Biomedical Engineering.
2018 Design of a precision medication dispenser: Preventing overdose by increasing accuracy and precision of dosage.
S. S. Srinivasan, S. N. R. Kantareddy, E. A. Nkwate, P. Meka, I. Chang, N. C. Hanumara, K. B. Ramadi
Journal of Translational Engineering in Health and Medicine
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2018 Proprioception from a neurally controlled lower-extremity prosthesis.
T. R. Clites, M. J. Carty, J. B. Ullauri, M. E. Carney, L. M. Mooney, J. Duval, S. S. Srinivasan, H. M. Herr
Science Translational Medicine
Read this publication on Science Translational Medicine.
2017 On prosthetic control: A regenerative agonist-antagonist myoneural interface.
S. S. Srinivasan, M. J. Carty, P. W. Calvaresi, T. R. Clites, B. E. Maimon, C. R. Taylor, A. N. Zorzos, H. M. Herr
Science Robotics
Making prosthetic limbs feel more natural
Muscle grafts could help amputees sense and control artificial limbs.
Anne Trafton | MIT News Office
May 31, 2017
New Approach to Amputation Could Reduce Phantom Pain
The technique, tested in rodents, could yield better sensation and control of prosthetic limbs.
Karen Weintraub | Scientific American
June 2, 2017
This new surgical procedure could lead to lifelike prosthetic limbs
Robotic joints could—for the first time—be controlled by opposing muscle grafts
Matthew Hutson | Science
May 31, 2017
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2017 Transdermal optogenetic peripheral nerve stimulation.
B. E. Maimon, A. N. Zorzos, R. Bendell, A. Harding, M. Fahmi, S. S. Srinivasan, P. Calvaresi, H. M. Herr
Journal of Neural Engineering
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2017 A murine model of a novel surgical architecture for proprioceptive muscle feedback and its potential application to control of advanced limb prostheses.
T. R. Clites, M. J. Carty, S. S. Srinivasan, A. N. Zorzos, H. M. Herr
Journal of Neural Engineering.
Read this publication on Journal of Neural Engineering.
2015 Control of surface ligand density on PEGylated gold nanoparticles for optimized cancer cell uptake.
H. Liu, T. L. Doane, Y. Cheng, F. Lu, S. S. Srinivasan, J. Zhu, C. Burda
Particle & Particle Systems Characterization
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2014 Observation and Photophysical Characterization of Silicon Phthalocyanine J‐Aggregate Dimers in Aqueous Solutions.
T. Doane, A. Chomas, S. S. Srinivasan, C. Burda
Chemistry–A European Journal
Read this publication on Chemistry–A European Journal.